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After birth, the symptoms of androgenization increase in children of lamivudine sexes. The size of the clitoris increases in the girl, its tension is noted. In boys, the size of the penis increases, erections appear. It should be noted that the symptoms of androgenization may not appear in the first 1.5 years of a child's life. By the age of 2-3, sexual hair growth and acne vulgaris appear in children of both sexes, the voice coarsens, and the muscles hypertrophy. In the first years of life, the linear growth of children is accelerated, but the degree of bone differentiation is ahead of growth, growth zones are closed by 9-10 years.
The degree of pre- and postnatal androgenization in patients with 21-hydroxylase deficiency can have significant individual variations even in sick siblings in the same family with the same genetic defect. This may be due to the individual characteristics of the metabolism of androgen precursors and the difference in androgen receptor activity in a particular patient.
Complete loss of 21-hydroxylase activity, present in 75% of children withdeficiency of P450c21 leads to a decrease in aldosterone biosynthesis. Aldosterone is necessary for normal sodium homeostasis, its deficiency leads to sodium loss through the kidneys, intestines, and sweat glands. The presence of a pronounced salt-losing component associated with mineralocorticoid deficiency poses a serious threat to buy combivir online from the first days of life. 3-4 days after birth, hyperkalemia increases, after a few days hyponatremia and hypernatriuria develop. Loss of salt leads to severe dehydration, weight loss. Dehydration is aggravated by frequent and massive vomiting caused by hyperkalemia. In the absence of therapy, the death of the child may occur as a result of collapse and cardiogenic shock.